4. Capture and Enrichment of Emerging Pathogens for Multiple and Ultra-Sensitive diagnostic (USDEP)


Funding code: LSHB-CT-2006-037560

The project funded by the European Union aims at the development of highly sensitive molecular diagnostic methods for fast multiplex detection of pathogenic germs in clinical samples. The focus is on agents that are currently without adequate or sufficiently sensitive diagnostics. Core element is sample preparation as wall as a PCR-based diagnostic. http://www.usdep.eu


Project partners:

Robert Koch-Institut
ImmunoClin Ltd
ApoH-Technologies
Institut de Recherche Pour le Développement
Pontificia Universidad Católica de Chile
Fraunhofer Institut für Siliziumtechnologie
AJ eBiochip
SKULDTECH
GenExpress GmbH

Also in the 21st century infectious diseases are still one of the main causes of death worldwide. The key to successful control and combating of current and future epidemics is fast, sensitive and reliable diagnostics of known and unknown pathogenic agents.
It was possible to identify the human protein apolipoprotein H (ApoH) as protein interacting with many different agents (viruses, bacteria and parasites). It may serve as a suitable candi-date for the development of a new enrichment technology.
The USDEP project succeeded in developing protocols on the basis of an ApoH-coated matrix to enrich various viral (dengue virus, hepatitis C virus, hanta virus, rotavirus and others), bacterial and parasitic agents from complex clinical material and to detect them via various PCR procedures. It was also possible to clearly increase sensitivity in comparison to existing standard procedures.
It fell to GenExpress to develop quantitative real-time multiplex PCR assays for the validation of the established protocols as well as the development of multiplex PCR systems for the DNA microarray prototypes in close cooperation with AJ eBiochip and SkuldTech. These were novel chip-based detection procedures for "point of care" diagnostics.

News

24.08.2018

You can now find updated descriptions and price examples of our services.

02.08.2018

Positive controls for your PCR: You can now find a selection of our product portfolio in the

Standards-sample-list (169 KB)

20.07.2018

Our privacy policy has been updated in accordance with the new EU General Data Protection Regulation (EU GDPR) >>>

11.01.2018

The new certificate

ISO 9001-2015 is now available. Go here for download.

08.01.2018

In November 2017 GenExpress successfully passed the recertification audit in compliance with ISO 9001:2015.

2017

Reconstruction of QMS ISO 9001 from 2008 to 2015 

18.06.2017

GenExpress is celebration its 20th anniversary at the historic "Malzfabrik Berlin"

22.06.2012

Completion of joint research profect BIGRUDI  >>read

18.03.2011

GenExpress website now also available in English.

06.01.2011

In December 2010 GenExpress successfully passed the recertification audit in compliance with ISO 9001:2008. The new certificates are available for download.

02.07.2010

GenExpress launches new website.

30.04.2010

Successful conclusion of the EU-funded USDEP project.  continue >>